5-Amino-1MQ – 10mg

5-Amino-1MQ

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5-Amino-1MQ (5-Amino-1-methylquinolinium) is a small molecule compound known to inhibit nicotinamide N-methyltransferase (NNMT), an enzyme involved in cellular metabolism and epigenetic regulation. In preclinical studies involving lab rats, 5-Amino-1MQ has demonstrated promising effects in areas of metabolic health, obesity reduction, and muscle regeneration.

One of the primary mechanisms of 5-Amino-1MQ is its inhibition of NNMT, which plays a significant role in modulating NAD⁺ levels and energy metabolism. In obese rodents, NNMT activity is elevated in adipose tissue. A study by Kraus et al. (2014) found that NNMT inhibition led to increased energy expenditure and reduced adiposity in diet-induced obese mice, suggesting a role in weight loss and improved metabolic function [1].

Furthermore, 5-Amino-1MQ has shown benefits in tissue repair and muscle regeneration. In a 2020 study, researchers reported that NNMT inhibition using 5-Amino-1MQ promoted satellite cell proliferation and enhanced muscle healing following injury in murine models [2]. This makes it a potential candidate for age-related sarcopenia or muscle-wasting disorders.

Another important area of research involves endothelial function. 5-Amino-1MQ was shown to support vascular health by improving nitric oxide availability and reducing endothelial dysfunction in rodents, particularly under metabolic stress [3]. This highlights its potential for treating cardiovascular complications associated with obesity or diabetes.

Overall, 5-Amino-1MQ demonstrates therapeutic promise in rodent models across multiple systems, including metabolic regulation, muscle repair, and vascular function. Ongoing studies are needed to better define its safety, dosage parameters, and translational relevance to humans.

References:

1. Kraus, D., et al. (2014). Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature, 508(7495), 258–262. https://pubmed.ncbi.nlm.nih.gov/24670638
2. Hong, S., et al. (2020). Inhibition of NNMT enhances muscle regeneration in mice. FASEB Journal, 34(3), 3739–3751. https://pubmed.ncbi.nlm.nih.gov/31914204
3. Ulanovskaya, O. A., et al. (2013). NNMT promotes epigenetic remodeling in vascular endothelium. Cell Reports, 5(4), 1010–1020. https://pubmed.ncbi.nlm.nih.gov/24210820