Adipotide (FTPP) 5mg
Adipotide (FTPP) 5mg
Original price was: $69.99.$57.99Current price is: $57.99.
5 mg per vial
- This product is prepared for PRESCRIBER USE ONLY and may not be used for other purposes.
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Properties
| Molecular Formula | |
|---|---|
| Molecular Weight | 2557.2 g/mol |
| Monoisotopic Mass | 2555.5243724 g/mol |
| Polar Area | |
| Complexity | 5220 |
| XLogP | -11.4 |
| Heavy Atom Count | 177 |
| Hydrogen Bond Donor Count | 40 |
| Hydrogen Bond Acceptor Count | 40 |
| Rotatable Bond Count | 98 |
| Physical Appearance | Fine White Lyophilized Powder |
| Stability | Store cold, keep refrigerated. Do NOT freeze. |
| PubChem LCSS |
Identifiers
| CID | 163360068 |
|---|---|
| CAS | 859216-15-2 |
| InChI | InChI=1S/C111H206N36O28S2/c1-60(2)49-79(142-99(163)71(32-15-23-41-113)133-87(150)56-125-86(149)55-127-97(161)84(59-177)147-109(173)83(53-89(152)153)146-103(167)76(36-19-27-45-117)138-90(154)64(9)128-98(162)72(39-30-48-123-111(121)122)134-88(151)57-124-85(148)54-126-96(160)70(31-14-22-40-112)139-95(159)69(120)58-176)105(169)129-66(11)92(156)136-74(34-17-25-43-115)101(165)143-80(50-61(3)4)106(170)130-65(10)91(155)135-73(33-16-24-42-114)100(164)140-77(37-20-28-46-118)104(168)145-82(52-63(7)8)107(171)131-67(12)93(157)137-75(35-18-26-44-116)102(166)144-81(51-62(5)6)108(172)132-68(13)94(158)141-78(110(174)175)38-21-29-47-119/h60-84,176-177H,14-59,112-120H2,1-13H3,(H,124,148)(H,125,149)(H,126,160)(H,127,161)(H,128,162)(H,129,169)(H,130,170)(H,131,171)(H,132,172)(H,133,150)(H,134,151)(H,135,155)(H,136,156)(H,137,157)(H,138,154)(H,139,159)(H,140,164)(H,141,158)(H,142,163)(H,143,165)(H,144,166)(H,145,168)(H,146,167)(H,147,173)(H,152,153)(H,174,175)(H4,121,122,123)/t64-,65+,66+,67+,68+,69-,70-,71+,72-,73+,74+,75+,76-,77+,78+,79+,80+,81+,82+,83-,84-/m0/s1 |
| InChIKey | GZESIPHLGJDZRG-VCWDIOOSSA-N |
| Isomeric SMILES | C[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CS)C(=O)NCC(=O)NCC(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](C)C(=O)N[C@H](CCCCN)C(=O)N[C@H](CC(C)C)C(=O)N[C@H](C)C(=O)N[C@H](CCCCN)C(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CS)N |
| Canonical SMILES | |
| IUPAC Name | L-cysteinyl-L-lysyl-glycyl-glycyl-L-arginyl-L-alanyl-L-lysyl-L-alpha-aspartyl-L-cysteinyl-glycyl-glycyl-D-lysyl-D-leucyl-D-alanyl-D-lysyl-D-leucyl-D-alanyl-D-lysyl-D-lysyl-D-leucyl-D-alanyl-D-lysyl-D-leucyl-D-alanyl-D-lysine |
Description
Adipotide
Product is sold for prescriber purposes only. Please handle with care and follow all safety guidelines for the specific chemicals involved.
Adipotide, a synthetic peptide developed to target obesity, has garnered attention in research involving animal models, particularly rats. It functions by selectively targeting and inducing apoptosis in the blood vessels supplying white adipose tissue, leading to reduced fat deposits. This characteristic makes it a promising therapeutic for obesity-related conditions, such as metabolic syndrome and type 2 diabetes.
In rat models, studies have shown that adipotide administration can result in significant weight loss, reduction of fat mass, and improved insulin sensitivity. Rats receiving adipotide exhibited decreased food intake, reduction in visceral fat, and better glucose tolerance, key indicators of its efficacy in combating obesity (Kolonin et al., 2004). Additionally, adipotide was found to specifically reduce fat without adversely affecting lean body mass, making it an appealing candidate for further investigation in clinical trials (Barnhart et al., 2011).
While the potential of adipotide is promising, there are also concerns about side effects such as renal toxicity, which have been observed in some animal studies. Further research is essential to explore the long-term safety and efficacy of adipotide in rats, which could provide crucial insights into its therapeutic potential for human obesity treatment.
References:
1. Kolonin, M. G., Saha, P. K., Chan, L., Pasqualini, R., & Arap, W. (2004). Reversal of obesity by targeted ablation of adipose tissue vasculature. *Nature Medicine*, 10(6), 625-632. https://pubmed.ncbi.nlm.nih.gov/15156201/
2. Barnhart, K. F., Christianson, D. R., Hanley, P. W., et al. (2011). A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys. *Science Translational Medicine*, 3(108), 108ra112. https://pubmed.ncbi.nlm.nih.gov/22030761/
Research chemicals are furnished for laboratory research purposes only and should only be handled by qualified, licensed professionals.
Research chemicals are chemical substances used by scientists for medical and scientific research purposes. One characteristic of a research chemical is that it is for laboratory research use only. A research chemical is not intended for human or veterinary use. This distinction is required on the labels of research chemicals, and is what exempts them from regulation under Parts 100-740, Code of Federal Regulations Title 21 (21 CFR Parts 100-740).
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