AOD9604 – 5mg
AOD9604 – 5mg
Original price was: $57.99.$44.99Current price is: $44.99.
5 mg per vial
- This product is prepared for PRESCRIBER USE ONLY and may not be used for other purposes.
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Properties
| Molecular Formula | C78H123N23O23S2 |
|---|---|
| Molecular Weight | 1815.1 |
| Monoisotopic Mass | 1813.86035961 |
| Polar Area | 815 |
| Complexity | 3710 |
| XLogP | -4.8 |
| Heavy Atom Count | 126 |
| Hydrogen Bond Donor Count | 28 |
| Hydrogen Bond Acceptor Count | 28 |
| Rotatable Bond Count | 45 |
| Physical Appearance | Fine White Lyophilized Powder |
| Stability | Lyophilized protein is to be stored at -20°C. It is recommended to aliquot the reconstituted (dissolved) protein into several discrete vials in order to avoid repeated freezing and thawing. Reconstituted protein can be stored at 4°C |
| PubChem LCSS |
Identifiers
| CID | 71300630 |
|---|---|
| CAS | 221231-10-3 |
| InChI | InChI=1S/C78H123N23O23S2/c1-9-41(8)62(101-68(115)47(18-14-28-86-78(83)84)91-69(116)50(29-38(2)3)95-63(110)45(79)30-43-19-21-44(104)22-20-43)75(122)100-61(40(6)7)74(121)94-49(23-25-56(80)105)67(114)98-55-37-126-125-36-54(65(112)88-32-57(106)89-51(76(123)124)31-42-15-11-10-12-16-42)97-70(117)52(34-102)90-58(107)33-87-64(111)48(24-26-59(108)109)93-73(120)60(39(4)5)99-71(118)53(35-103)96-66(113)46(92-72(55)119)17-13-27-85-77(81)82/h10-12, 15-16, 19-22, 38-41, 45-55, 60-62, 102-104H, 9, 13-14, 17-18, 23-37, 79H2, 1-8H3, (H2, 80, 105)(H, 87, 111)(H, 88, 112)(H, 89, 106)(H, 90, 107)(H, 91, 116)(H, 92, 119)(H, 93, 120)(H, 94, 121)(H, 95, 110)(H, 96, 113)(H, 97, 117)(H, 98, 114)(H, 99, 118)(H, 100, 122)(H, 101, 115)(H, 108, 109)(H, 123, 124)(H4, 81, 82, 85)(H4, 83, 84, 86)/t41-, 45-, 46-, 47-, 48-, 49-, 50-, 51-, 52-, 53-, 54-, 55-, 60-, 61-, 62-/m0/s1 |
| InChIKey | GVIYUKXRXPXMQM-BPXGDYAESA-N |
| Isomeric SMILES | CC[C@H](C)[C@@H](C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCCNC(=N)N)CO)C(C)C)CCC(=O)O)CO)C(=O)NCC(=O)N[C@@H](CC2=CC=CC=C2)C(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC3=CC=C(C=C3)O)N |
| Canonical SMILES | CCC(C)C(C(=O)NC(C(C)C)C(=O)NC(CCC(=O)N)C(=O)NC1CSSCC(NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CCCNC(=N)N)CO)C(C)C)CCC(=O)O)CO)C(=O)NCC(=O)NC(CC2=CC=CC=C2)C(=O)O)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CC3=CC=C(C=C3)O)N |
| IUPAC Name | (2S)-2-[[2-[[(4R, 7S, 13S, 16S, 19S, 22S, 25R)-25-[[(2S)-5-amino-2-[[(2S)-2-[[(2S, 3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylpentanoyl]amino]-3-methylbutanoyl]amino]-5-oxopentanoyl]amino]-22-(3-carbamimidamidopropyl)-13-(2-carboxyethyl)-7, 19-bis(hydroxymethyl)-6, 9, 12, 15, 18, 21, 24-heptaoxo-16-propan-2-yl-1, 2-dithia-5, 8, 11, 14, 17, 20, 23-heptazacyclohexacosane-4-carbonyl]amino]acetyl]amino]-3-phenylpropanoic acid |
Description
AOD9604
Product is sold for prescriber purposes only. Please handle with care and follow all safety guidelines for the specific chemicals involved.
AOD9604, a stabilized analog of human growth hormone fragment 176-191, has been investigated for its potential lipolytic (fat-burning) effects. Research in rat models has played a significant role in understanding AOD9604’s mechanisms of action and its effects on metabolic parameters.
Rat studies have explored various aspects of AOD9604’s effects. These studies often involve administering AOD9604 to rats through subcutaneous injections and then monitoring changes in body composition, particularly fat mass. Researchers have examined the impact of AOD9604 on different types of adipose tissue, including visceral and subcutaneous fat.
One key area of investigation in rat studies is the determination of the optimal dosage and duration of AOD9604 administration. Researchers aim to identify the dosage range that produces the desired lipolytic effects without causing significant adverse effects. These studies also explore how long the effects of AOD9604 persist after administration.
Rat models also allow for detailed analysis of the biochemical changes associated with AOD9604 treatment. Researchers have examined how AOD9604 affects the activity of enzymes involved in lipolysis, such as hormone-sensitive lipase (HSL). They have also investigated how AOD9604 influences the expression of genes related to fat metabolism.
Furthermore, studies in rats have explored the potential effects of AOD9604 on other metabolic parameters, such as insulin sensitivity and glucose metabolism. Some research suggests that AOD9604 may improve insulin sensitivity, which is beneficial for individuals with metabolic disorders.
It’s important to note that while rat studies provide valuable insights into the potential of AOD9604, translating these findings to humans requires further investigation. The physiological differences between rats and humans, as well as differences in drug metabolism, must be considered.
In conclusion, rat research has been instrumental in understanding the effects of AOD9604 on fat metabolism and other metabolic parameters. These studies have provided a foundation for further research into the potential therapeutic applications of AOD9604.
References
While pinpointing only rat-specific studies within the broader AOD9604 research landscape can be challenging, here are some references that include relevant animal model work and provide context:
- Ng, F. M., et al. “Effects of an amino-terminal fragment of human growth hormone on lipolysis in the rat.” Journal of Endocrinology, vol. 128, no. 3, 1991, pp. 357-62. https://joe.bioscientifica.com/view/journals/joe/128/3/joe_128_3_002.xml
- Trenell, M. I., et al. “Growth hormone secretagogue receptor expression and function in human adipose tissue.” Journal of Endocrinology, vol. 183, no. 2, 2004, pp. 287-95. https://joe.bioscientifica.com/view/journals/joe/183/2/joe_183_2_011.xml
- Heffernan, M. A., et al. “The effect of oral administration of AOD9604 on body composition and lipid metabolism in high-fat fed obese mice.” International Journal of Obesity, vol. 25, no. 8, 2001, pp. 1192-99.
- “AOD 9604 – Wikipedia.” Wikipedia, Wikimedia Foundation, 10 Apr. 2024, https://en.wikipedia.org/wiki/AOD_9604.
- “Fragment 176-191 – an overview | ScienceDirect Topics.” ScienceDirect, https://www.sciencedirect.com/topics/neuroscience/fragment-176-191.
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