Description
Cardiogen
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Cardiogen is a peptide bioregulator derived from heart tissue, designed to support cardiovascular health by modulating gene expression and protein synthesis in myocardial cells. Peptide bioregulators such as Cardiogen are part of a broader category of cytomedines developed in Russia for targeted organ support and regeneration. In preclinical studies using laboratory rats, Cardiogen has shown promising effects on cardiac function, stress adaptation, and myocardial recovery after injury.
In rat models, Cardiogen has been observed to improve heart rate variability, reduce arrhythmias, and promote myocardial regeneration following induced ischemia or toxic cardiac damage. One study demonstrated that administration of Cardiogen led to a significant increase in antioxidant enzyme activity and reduction in lipid peroxidation markers in rats with chemically-induced cardiac stress, suggesting it protects the myocardium through oxidative stress modulation (Korkushko et al., 2012).
Further, Cardiogen has been evaluated for its effects on gene expression. It appears to influence the expression of genes related to cardiac muscle contraction, mitochondrial function, and anti-apoptotic signaling. A 2021 study reported that peptide-based regulation improved mitochondrial respiration and ATP synthesis in cardiomyocytes of aging rats, pointing to a role in restoring age-related cardiac decline (Khavinson et al., 2021).
Additionally, Cardiogen has been associated with enhanced adaptation to physical and emotional stress in rats, possibly through the hypothalamic-pituitary-adrenal (HPA) axis modulation, thereby indirectly supporting cardiac function under chronic stress conditions (Trofimova et al., 2018).
In conclusion, Cardiogen demonstrates cardioprotective and regenerative properties in laboratory rats, primarily by reducing oxidative damage, supporting gene expression, and stabilizing myocardial function. These findings suggest that Cardiogen may be a valuable peptide for cardiovascular therapy, warranting further investigation in human clinical settings.
References:
- Korkushko, O.V., et al. (2012). PubMed ID: 22708326
- Khavinson, V.K., et al. (2021). PubMed ID: 33765835
- Trofimova, S.V., et al. (2018). PubMed ID: 29892157
