Cerebrolysin – 1200mg

Cerebrolysin

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Cerebrolysin, a neuropeptide preparation, has been extensively studied in rat models to evaluate its potential in treating neurological impairments. Research indicates that Cerebrolysin can significantly enhance cognitive functions and promote neuroprotection following brain injuries.

In a study by Zhang et al., rats subjected to mild traumatic brain injury (mTBI) were treated with Cerebrolysin. The results demonstrated notable improvements in long-term spatial learning and memory, as assessed by the Morris water maze test. Additionally, treated rats exhibited reduced accumulation of amyloid precursor protein and decreased astrogliosis, suggesting neuroprotective effects.

Another randomized controlled trial investigated the effects of Cerebrolysin on rats with moderate closed head injury. The findings revealed that Cerebrolysin treatment significantly improved long-term functional and histological outcomes. These improvements were correlated with enhanced neuroplasticity and neuroprotection, indicating the therapeutic potential of Cerebrolysin in traumatic brain injuries.

Furthermore, research by Zhang et al. explored the impact of Cerebrolysin on social interaction and recognition memory in rats post-injury. The study found that Cerebrolysin-treated rats spent significantly more time exploring novel objects and odors compared to vehicle-treated rats, suggesting improvements in non-spatial recognition memory. These behavioral enhancements were accompanied by reductions in tau protein accumulation and increased neuronal survival in specific brain regions.

These studies collectively suggest that Cerebrolysin holds promise as a therapeutic agent for enhancing cognitive function and promoting neuroprotection in rat models of brain injury.

References:

Zhang, Y., Chopp, M., Meng, Y., Zhang, Z. G., Doppler, E., Mahmood, A., & Xiong, Y. (2015). Cerebrolysin improves cognitive performance in rats after mild traumatic brain injury. Journal of Neurosurgery, 122(4), 843–855. https://thejns.org/view/journals/j-neurosurg/122/4/article-p843.xml

Zhang, Y., Chopp, M., Zhang, Z. G., Zhang, Y., Zhang, L., Lu, M., Zhang, T., Winter, S., Doppler, E., Brandstäetter, H., Mahmood, A., & Xiong, Y. (2019). Cerebrolysin reduces astrogliosis and axonal injury and enhances neurogenesis in rats after closed head injury. Neurorehabilitation and Neural Repair, 33(1), 15–26. https://pubmed.ncbi.nlm.nih.gov/30499355/

Zhang, Y., Chopp, M., Zhang, Z. G., Zhang, Y., Zhang, L., Lu, M., Zhang, T., Winter, S., Doppler, E., Brandstäetter, H., Mahmood, A., & Xiong, Y. (2020). Randomized controlled trial of Cerebrolysin’s effects on long-term histological outcomes and functional recovery in rats with moderate closed head injury. Journal of Neurosurgery, 133(4), 1072–1083. https://thejns.org/view/journals/j-neurosurg/133/4/article-p1072.xml