DSIP – 5mg
DSIP – 5mg
Original price was: $49.99.$39.99Current price is: $39.99.
5 mg per vial
- This product is prepared for PRESCRIBER USE ONLY and may not be used for other purposes.
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Properties
| Molecular Formula | C35H48N10O15 |
|---|---|
| Molecular Weight | 848.8 g/mol |
| Monoisotopic Mass | 848.33006086 Da |
| Polar Area | |
| Complexity | 1610 |
| XLogP | -7.1 |
| Heavy Atom Count | 60 |
| Hydrogen Bond Donor Count | 14 |
| Hydrogen Bond Acceptor Count | 16 |
| Rotatable Bond Count | 25 |
| Physical Appearance | Fine White Lyophilized Powder |
| Stability | |
| PubChem LCSS |
Identifiers
| CID | 68816 |
|---|---|
| CAS | 62568-57-4 |
| InChI | InChI=1S/C35H48N10O15/c1-16(41-32(56)20(36)9-18-11-37-21-6-4-3-5-19(18)21)30(54)39-12-25(47)38-13-26(48)44-23(10-29(52)53)34(58)42-17(2)31(55)45-24(15-46)33(57)40-14-27(49)43-22(35(59)60)7-8-28(50)51/h3-6,11,16-17,20,22-24,37,46H,7-10,12-15,36H2,1-2H3,(H,38,47)(H,39,54)(H,40,57)(H,41,56)(H,42,58)(H,43,49)(H,44,48)(H,45,55)(H,50,51)(H,52,53)(H,59,60) |
| InChIKey | ZRZROXNBKJAOKB-UHFFFAOYSA-N |
| Isomeric SMILES | CC(C(=O)NCC(=O)NCC(=O)NC(CC(=O)O)C(=O)NC(C)C(=O)NC(CO)C(=O)NCC(=O)NC(CCC(=O)O)C(=O)O)NC(=O)C(CC1=CNC2=CC=CC=C21)N |
| Canonical SMILES | |
| IUPAC Name | 2-[[2-[[2-[2-[[2-[[2-[[2-[2-[[2-amino-3-(1H-indol-3-yl)propanoyl]amino]propanoylamino]acetyl]amino]acetyl]amino]-3-carboxypropanoyl]amino]propanoylamino]-3-hydroxypropanoyl]amino]acetyl]amino]pentanedioic acid |
Description
DSIP (Delta Sleep-Inducing Peptide)
Product is sold for prescriber purposes only. Please handle with care and follow all safety guidelines for the specific chemicals involved.
Delta sleep-inducing peptide (DSIP) is a nonapeptide originally isolated from rabbit cerebral venous blood, renowned for its multifaceted physiological effects. In rat models, DSIP has been extensively studied for its roles in sleep modulation, neuroprotection, mitochondrial function, and endocrine regulation.(PubMed)
Beyond sleep, DSIP exhibits significant neuroprotective properties. In conditions of hypoxia-induced stress, DSIP has been shown to improve mitochondrial oxidative phosphorylation efficiency in rat brain mitochondria, thereby enhancing ATP production and potentially mitigating neuronal damage. (PubMed)
DSIP also modulates neurotransmitter systems. It has been observed to influence the activity of monoamine oxidase A (MAO-A) and alter serotonin levels in the rat brain, indicating its potential in regulating mood and stress responses. (PubMed)
Furthermore, DSIP’s role in endocrine regulation is evident through its modulation of pineal gland activity. Research indicates that DSIP can affect the activity of N-acetyltransferase (NAT) in the rat pineal gland, an enzyme crucial for melatonin synthesis, thereby implicating DSIP in circadian rhythm regulation. (PubMed)
In developmental studies, DSIP-like immunoreactivity has been detected in various regions of the rat brain, with concentrations varying during different developmental stages. This suggests a role for DSIP in brain maturation and function. (PubMed)
In conclusion, DSIP’s diverse physiological effects in rat models underscore its potential as a therapeutic agent. Its involvement in sleep regulation, neuroprotection, neurotransmitter modulation, and endocrine function presents numerous avenues for future research, particularly in understanding its mechanisms and potential clinical applications.(PubMed)
References:
- Graf, M. V., & Schoenenberger, G. A. (1986). DSIP affects adrenergic stimulation of rat pineal N-acetyltransferase in vivo and in vitro. Peptides, 7(6), 1001–1006. https://pubmed.ncbi.nlm.nih.gov/3562314/
- Graf, M. V., & Schoenenberger, G. A. (1988). Evidence for a role of delta sleep-inducing peptide in slow wave sleep and growth hormone release in rats. Peptides, 9(2), 273–279. https://pubmed.ncbi.nlm.nih.gov/3368469/
- Umriukhin, P. E., Koplik, E. V., & Sudakov, K. V. (2003). Effects of delta-sleep-inducing peptide in cerebral ischemia in rats. Ross Fiziol Zh Im I M Sechenova, 89(1), 3–7. https://pubmed.ncbi.nlm.nih.gov/12669586/
- Umriukhin, P. E., Anokhin, K. V., & Raevskiĭ, K. S. (2003). Effects of delta-sleep-inducing peptide during ischemic injury of the rat brain. Neuroscience and Behavioral Physiology, 33(7), 697–701. https://pubmed.ncbi.nlm.nih.gov/12436688/
- Kastin, A. J., Nissen, C., & Coy, D. H. (1981). DSIP-like immunoreactivity in the developing rat brain. Brain Research Bulletin, 7(6), 687–690. https://pubmed.ncbi.nlm.nih.gov/6895711/
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