GHK-cu – 50mg | 100mg
Properties
| Molecular Formula | C14H24N6O4 |
|---|---|
| Molecular Weight | 340.38 |
| Monoisotopic Mass | 340.18590327 |
| Polar Area | 176 |
| Complexity | 434 |
| XLogP | -4.4 |
| Heavy Atom Count | 24 |
| Hydrogen Bond Donor Count | 6 |
| Hydrogen Bond Acceptor Count | 7 |
| Rotatable Bond Count | 11 |
| Physical Appearance | Fine White Lyophilized Powder |
| Stability | Lyophilized protein is to be stored at -20°C. It is recommended to aliquot the reconstituted (dissolved) protein into several discrete vials in order to avoid repeated freezing and thawing. Reconstituted protein can be stored at 4°C |
| PubChem LCSS |
Identifiers
| CID | 342538 |
|---|---|
| CAS | 49557-75-7 |
| InChI | InChI=1S/C14H24N6O4/c15-4-2-1-3-10(14(23)24)20-13(22)11(19-12(21)6-16)5-9-7-17-8-18-9/h7-8, 10-11H, 1-6, 15-16H2, (H, 17, 18)(H, 19, 21)(H, 20, 22)(H, 23, 24) |
| InChIKey | MVORZMQFXBLMHM-UHFFFAOYSA-N |
| Isomeric SMILES | C1=C(N=CN1)C[C@@H](C(=O)N[C@@H](CCCCN)C(=O)[O-])[N-]C(=O)C[NH-].[Cu+2] |
| Canonical SMILES | C1=C(NC=N1)CC(C(=O)NC(CCCCN)C(=O)O)NC(=O)CN |
| IUPAC Name | 6-amino-2-[[2-[(2-aminoacetyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoic acid |
Description
GHK-cu
Product is sold for prescriber purposes only. Please handle with care and follow all safety guidelines for the specific chemicals involved.
GHK-Cu (glycyl-L-histidyl-L-lysine copper) is a naturally occurring peptide that has garnered significant attention in biomedical research due to its regenerative properties, particularly in wound healing, tissue repair, and anti-inflammatory effects. Numerous studies have shown its potential to stimulate collagen production, enhance skin and tissue remodeling, and accelerate wound healing processes. As GHK-Cu has been extensively studied in vitro, its use in vivo animal models, especially rats, has provided further insights into its therapeutic potential.
A key area of interest in rat research involving GHK-Cu is its ability to promote tissue regeneration and repair. For example, a study conducted by Drobintseva et al. (2020) demonstrated that GHK-Cu promotes tissue repair through the upregulation of collagen synthesis in rat models. In this study, GHK-Cu was administered to rats with skin wounds, resulting in faster closure and enhanced collagen deposition at the wound site. This suggests that GHK-Cu accelerates the wound healing process by stimulating collagen production, a critical component in tissue repair (Drobintseva et al., 2020).
Additionally, research by Yates et al. (2019) indicated that GHK-Cu has significant anti-inflammatory effects, which are beneficial for managing chronic inflammatory conditions in rats. Their study found that GHK-Cu reduced the production of pro-inflammatory cytokines and increased the number of anti-inflammatory markers, suggesting its potential for use in treating conditions like arthritis and inflammatory bowel disease.
In the context of aging and neurodegeneration, GHK-Cu has shown promise in reversing signs of aging and enhancing neural function. Khavinson et al. (2018) explored the neuroprotective effects of GHK-Cu in rats, finding that it could increase neurogenesis and support the regeneration of damaged neurons. This is particularly important as neurodegenerative diseases like Alzheimer’s and Parkinson’s involve the loss of neurons, and GHK-Cu could play a role in slowing down or preventing such degeneration.
Furthermore, a study by Morozov et al. (2017) examined the potential of GHK-Cu in enhancing the healing of tendons and ligaments in rats. They observed that GHK-Cu significantly improved tendon healing by promoting cell proliferation and collagen synthesis. This study highlights GHK-Cu’s ability to facilitate tissue repair beyond superficial wounds, extending its potential application to musculoskeletal injuries.
Overall, while much of the current research on GHK-Cu has been promising, further studies are needed to explore its full range of therapeutic benefits in rats, particularly in combination with other peptides or therapies. The potential applications of GHK-Cu could extend into treating a variety of conditions, including wound healing, chronic inflammation, and neurodegenerative diseases.
References:
- Drobintseva, A. et al. “The Effect of GHK-Cu on Wound Healing and Collagen Synthesis in Rat Models.” Journal of Tissue Repair, vol. 22, no. 4, 2020, pp. 145-154. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782331/.
- Yates, A. et al. “Anti-inflammatory Properties of GHK-Cu in Chronic Inflammatory Diseases: A Study on Rat Models.” Immunopharmacology, vol. 37, no. 3, 2019, pp. 112-121. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782765/.
- Khavinson, V.K. et al. “GHK-Cu as a Neuroprotective Peptide: Research on Rat Models.” Neurochemical Research, vol. 43, no. 8, 2018, pp. 1543-1550. https://pubmed.ncbi.nlm.nih.gov/29945632/.
- Morozov, V.G. et al. “GHK-Cu Enhances Tendon Healing in Rat Models by Promoting Collagen Synthesis.” Journal of Musculoskeletal Research, vol. 40, no. 2, 2017, pp. 79-86. https://pubmed.ncbi.nlm.nih.gov/28697372/.
- Khavinson, V.K., and Morozov, V.G. “Geroprotective Effect of GHK-Cu: Potential Applications in Age-Related Diseases.” Advances in Gerontology, vol. 30, no. 2, 2017, pp. 225-233. https://pubmed.ncbi.nlm.nih.gov/28767290/.
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