GLP-1 Semaglutide 5mg | 10mg | 20mg
GLP-1 Semaglutide 5mg | 10mg | 20mg
Price range: $55.00 through $899.00
5 mg per vial | 10mg per vial | 20mg per vial
- This product is prepared for PRESCRIBER USE ONLY and may not be used for other purposes.
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Properties
| Molecular Formula | C187H291N45O59 |
|---|---|
| Molecular Weight | 4114 |
| Monoisotopic Mass | 4111.1153770 |
| Polar Area | 1650 |
| Complexity | 9590 |
| XLogP | -5.8 |
| Heavy Atom Count | 291 |
| Hydrogen Bond Donor Count | 57 |
| Hydrogen Bond Acceptor Count | 63 |
| Rotatable Bond Count | 151 |
| Physical Appearance | Fine White Lyophilized Powder |
| Stability | Lyophilized protein is to be stored at -20°C. It is recommended to aliquot the reconstituted (dissolved) protein into several discrete vials in order to avoid repeated freezing and thawing. Reconstituted protein can be stored at 4°C |
| PubChem LCSS |
Identifiers
| CID | 5643331 |
|---|---|
| CAS | 910463-68-2 |
| InChI | InChI=1S/C187H291N45O59/c1-18-105(10)154(180(282)208-108(13)159(261)216-133(86-114-89-200-119-50-40-39-49-117(114)119)170(272)218-129(82-102(4)5)171(273)228-152(103(6)7)178(280)215-121(53-44-72-199-186(192)193)162(264)201-91-141(242)209-120(52-43-71-198-185(190)191)161(263)204-94-151(257)258)230-172(274)131(83-111-45-33-31-34-46-111)219-167(269)126(64-69-149(253)254)214-166(268)122(51-41-42-70-195-144(245)98-290-79-78-289-76-74-197-145(246)99-291-80-77-288-75-73-196-139(240)66-61-127(183(285)286)211-140(241)54-37-29-27-25-23-21-19-20-22-24-26-28-30-38-55-146(247)248)212-158(260)107(12)206-157(259)106(11)207-165(267)125(60-65-138(189)239)210-142(243)92-202-163(265)123(62-67-147(249)250)213-168(270)128(81-101(2)3)217-169(271)130(85-113-56-58-116(238)59-57-113)220-175(277)135(95-233)223-177(279)137(97-235)224-179(281)153(104(8)9)229-174(276)134(88-150(255)256)221-176(278)136(96-234)225-182(284)156(110(15)237)231-173(275)132(84-112-47-35-32-36-48-112)222-181(283)155(109(14)236)227-143(244)93-203-164(266)124(63-68-148(251)252)226-184(287)187(16, 17)232-160(262)118(188)87-115-90-194-100-205-115/h31-36, 39-40, 45-50, 56-59, 89-90, 100-110, 118, 120-137, 152-156, 200, 233-238H, 18-30, 37-38, 41-44, 51-55, 60-88, 91-99, 188H2, 1-17H3, (H2, 189, 239)(H, 194, 205)(H, 195, 245)(H, 196, 240)(H, 197, 246)(H, 201, 264)(H, 202, 265)(H, 203, 266)(H, 204, 263)(H, 206, 259)(H, 207, 267)(H, 208, 282)(H, 209, 242)(H, 210, 243)(H, 211, 241)(H, 212, 260)(H, 213, 270)(H, 214, 268)(H, 215, 280)(H, 216, 261)(H, 217, 271)(H, 218, 272)(H, 219, 269)(H, 220, 277)(H, 221, 278)(H, 222, 283)(H, 223, 279)(H, 224, 281)(H, 225, 284)(H, 226, 287)(H, 227, 244)(H, 228, 273)(H, 229, 276)(H, 230, 274)(H, 231, 275)(H, 232, 262)(H, 247, 248)(H, 249, 250)(H, 251, 252)(H, 253, 254)(H, 255, 256)(H, 257, 258)(H, 285, 286)(H4, 190, 191, 198)(H4, 192, 193, 199)/t105-, 106-, 107-, 108-, 109+, 110+, 118-, 120-, 121-, 122-, 123-, 124-, 125-, 126-, 127+, 128-, 129-, 130-, 131-, 132-, 133-, 134-, 135-, 136-, 137-, 152-, 153-, 154-, 155-, 156-/m0/s1 |
| InChIKey | DLSWIYLPEUIQAV-CCUURXOWSA-N |
| Isomeric SMILES | CC[C@H](C)[C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)O)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](C(=O)O)NC(=O)CCCCCCCCCCCCCCCCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)N)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC5=CC=CC=C5)NC(=O)[C@H]([C@@H](C)O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)C(C)(C)NC(=O)[C@H](CC6=CN=CN6)N |
| Canonical SMILES | CCC(C)C(C(=O)NC(C)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)O)NC(=O)C(CC3=CC=CC=C3)NC(=O)C(CCC(=O)O)NC(=O)C(CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CCC(C(=O)O)NC(=O)CCCCCCCCCCCCCCCCC(=O)O)NC(=O)C(C)NC(=O)C(C)NC(=O)C(CCC(=O)N)NC(=O)CNC(=O)C(CCC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(C(C)C)NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(CC5=CC=CC=C5)NC(=O)C(C(C)O)NC(=O)CNC(=O)C(CCC(=O)O)NC(=O)C(C)(C)NC(=O)C(CC6=CN=CN6)N |
| IUPAC Name | 18-[[(1R)-4-[2-[2-[2-[2-[2-[2-[[(5S)-5-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S, 3R)-2-[[(2S)-2-[[(2S, 3R)-2-[[2-[[(2S)-2-[[2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-2-methylpropanoyl]amino]-4-carboxybutanoyl]amino]acetyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoyl]amino]-4-carboxybutanoyl]amino]acetyl]amino]-5-oxopentanoyl]amino]propanoyl]amino]propanoyl]amino]-6-[[(2S)-1-[[(2S)-1-[[(2S, 3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-carbamimidamido-1-[[2-[[(2S)-5-carbamimidamido-1-(carboxymethylamino)-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-6-oxohexyl]amino]-2-oxoethoxy]ethoxy]ethylamino]-2-oxoethoxy]ethoxy]ethylamino]-1-carboxy-4-oxobutyl]amino]-18-oxooctadecanoic acid |
Description
GLP-1 Sema (Analogue)
Product is sold for prescriber purposes only. Please handle with care and follow all safety guidelines for the specific chemicals involved.
In rodent models, semaglutide has been shown to produce multiple metabolic and neurophysiological effects beyond simply reducing glucose. For example, in a detailed study of diet-induced obese rats, semaglutide significantly reduced food intake, body weight, and modulated meal size rather than meal number, implying a dominant effect on meal termination circuits. (PubMed)
Mechanistically, one investigation found that semaglutide accesses discrete brainstem and hypothalamic regions (via circumventricular organs rather than bulk crossing the blood-brain barrier) and triggers c‐Fos activation in multiple nuclei involved in appetite control and reward, thereby altering neural pathways that regulate feeding behaviour. (PubMed) Another key rodent pharmacokinetic study characterised semaglutide’s plasma half-life (~7–9 h in rats) and demonstrated that brain uptake (brain‐to-plasma partition coefficient) is extremely low (<0.01), although concentrations were somewhat higher in the hypothalamus than in other brain regions. (PubMed)
Further, in a myocardial infarction model in rats, semaglutide treatment reduced body-weight, blood‐glucose and lipid levels, improved left ventricular ejection fraction, reduced myocardial fibrosis, and altered myocardial metabolism (via untargeted metabolomics) to reflect beneficial remodeling of amino sugar/nucleotide sugar, lipid and organic acid pathways. (PubMed) Together, these studies demonstrate that semaglutide in rats exerts broad systemic effects: appetite suppression via central neural pathways, altered feeding behaviour, favourable metabolic remodelling in tissues (including cardiac tissue), and clearly defined pharmacokinetic parameters. They also highlight that many of its central nervous system effects in rodents are mediated via specific circumventricular and hypothalamic GLP-1 receptor populations rather than widespread brain penetration.
References
- “Semaglutide lowers body weight in rodents via distributed neural pathways.” (rats) (PubMed)
- “Novel LC-MS/MS analysis of the GLP-1 analog semaglutide with its application to pharmacokinetics and brain distribution studies in rats.” (PubMed)
- “Cardiometabolic Modulation by Semaglutide Contributes to Cardioprotection in Rats with Myocardial Infarction.” (PubMed)
If you like, I can pull together a table of rat-studies by dose, duration, and outcome for semaglutide to give you a broader view.
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