KPV – 10mg

KPV

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KPV (Lys-Pro-Val) is a tripeptide derived from the C-terminal sequence of alpha-melanocyte-stimulating hormone (α-MSH), recognized for its anti-inflammatory properties. Recent studies have explored its potential in modulating inflammatory responses in various rat models.(PubMed)

In a study by Liu et al., KPV administration in scalded rats demonstrated a significant modulation of glucocorticoid receptor activity in hepatic cytosols, suggesting its role in regulating stress-induced inflammatory responses. (PubMed)

Further research by the same group observed that KPV treatment could prevent the reduction of mineralocorticoid receptor binding capacity in kidney cytosols of rats subjected to severe scald injuries. (PubMed)

Additionally, a study investigating the effects of a dimeric form of KPV, (CKPV)₂, found that it effectively inhibited tumor necrosis factor-alpha (TNF-α) production in lipopolysaccharide (LPS)-stimulated human peripheral blood mononuclear cells and reduced circulating TNF-α levels in rats challenged with LPS. (PubMed)

These findings collectively suggest that KPV and its derivatives may serve as potential therapeutic agents in managing inflammatory conditions. However, further studies are necessary to fully elucidate their mechanisms and efficacy in clinical settings.

References

• Liu, D. H., Su, Y. P., Zhang, W., Lou, S. F., Ran, X. Z., Gao, J. S., & Cheng, T. M. (2002). Downregulation of glucocorticoid receptors of liver cytosols and the role of the inflammatory cytokines in pathological stress in scalded rats. Burns, 28(4), 315–320. https://pubmed.ncbi.nlm.nih.gov/12052369/
• Liu, D. H., Su, Y. P., Zhang, W., Lou, S. F., Ran, X. Z., Gao, J. S., & Cheng, T. M. (2002). Changes in glucocorticoid and mineralocorticoid receptors of liver and kidney cytosols after pathologic stress and its regulation in rats. Critical Care Medicine, 30(3), 623–627. https://pubmed.ncbi.nlm.nih.gov/11990926/
• Catania, A., Gatti, S., Colombo, G., & Lipton, J. M. (2006). Inhibitory effects of the peptide (CKPV)₂ on endotoxin-induced host reactions. Peptides, 27(9), 2122–2129. https://pubmed.ncbi.nlm.nih.gov/16413580/
• Keremi, B., Lohinai, Z., Komora, P., Duhaj, S., Borsi, K., Jobbagy-Ovari, G., … & Varga, G. (2009). Antiinflammatory effect of BPC 157 on experimental periodontitis in rats. Journal of Physiology and Pharmacology, 60(Suppl 7), 115–122. https://pubmed.ncbi.nlm.nih.gov/20388954/
• Gopalakrishnan, S., Tripathi, A., Tamiz, A. P., Alkan, S. S., & Pandey, N. B. (2012). Larazotide acetate regulates epithelial tight junctions in vitro and in vivo. Peptides, 35(1), 95–101. https://pubmed.ncbi.nlm.nih.gov/22401908/