Description
Livagen
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Livagen is a synthetic short peptide bioregulator derived from the thymus, known for modulating gene expression and epigenetic regulation. It has been primarily studied for its role in immune function, cellular regeneration, and aging-related conditions. In laboratory rats, Livagen has shown significant promise in regulating gene activity, particularly through its impact on chromatin structure and DNA methylation.
In one study, Livagen was administered to rats to investigate its epigenetic activity on immune system-related genes. Results showed that Livagen influenced histone acetylation and DNA methylation patterns, leading to normalization of gene expression in aged animals, which suggests its potential in modulating age-related immune decline (Khavinson et al., 2004).
Additionally, Livagen has demonstrated protective effects in models of stress and aging. In a rat model, Livagen improved the expression of genes involved in cellular repair and immune function. This included upregulation of genes associated with chromatin remodeling and downregulation of pro-inflammatory markers (Trofimova et al., 2021).
Moreover, a comparative study found that Livagen, along with other short peptides, could reverse epigenetic age markers in rat tissues, indicating its use as a geroprotective agent. Treated animals displayed improved physiological responses and reduced signs of tissue degeneration (Khavinson et al., 2011).
These findings support Livagen’s utility in preclinical models for studying anti-aging, immune modulation, and epigenetic reprogramming.
References
- Khavinson, V.K., Morozov, V.G., & Malinin, V.V. (2004). Peptides in the epigenetic regulation of gene expression. Bulletin of Experimental Biology and Medicine, 137(5), 543–546. https://pubmed.ncbi.nlm.nih.gov/15341238/
- Trofimova, S.V., et al. (2021). Short peptides regulate gene expression and physiological functions in rats. International Journal of Molecular Sciences, 22(11), 5823. https://pubmed.ncbi.nlm.nih.gov/34066167/
- Khavinson, V.K., et al. (2011). Geroprotective effect of peptide bioregulators in rat models of aging. Neuro Endocrinol Lett, 32(6), 816–821. https://pubmed.ncbi.nlm.nih.gov/22167144/
