MOTS-c 20mg Peptide
MOTS-c 20mg Peptide
$69.99
20 mg per vial
- This product is prepared for PRESCRIBER USE ONLY and may not be used for other purposes.
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Properties
| Molecular Formula | C101H152N28O22S2 |
|---|---|
| Molecular Weight | 2174.6 g/mol |
| Monoisotopic Mass | 2173.1077409 g/mol |
| Polar Area | 890A2 |
| Complexity | 4510 |
| XLogP | |
| Heavy Atom Count | |
| Hydrogen Bond Donor Count | 31 |
| Hydrogen Bond Acceptor Count | 29 |
| Rotatable Bond Count | 73 |
| Physical Appearance | Fine White Lyophilized Powder |
| Stability | Lyophilized protein is to be stored at -20°C. It is recommended to aliquot the reconstituted (dissolved) protein into several discrete vials in order to avoid repeated freezing and thawing. Reconstituted protein can be stored at 4°C |
| PubChem LCSS |
Identifiers
| CID | 146675088 |
|---|---|
| CAS | 1627580-64-6 |
| InChI | InChI=1S/C101H152N28O22S2/c1-7-57(4)83(96(148)126-76(50-58-19-9-8-10-20-58)92(144)127-78(52-60-30-34-63(131)35-31-60)97(149)129-46-18-27-79(129)95(147)122-69(25-16-44-112-100(107)108)86(138)118-67(23-13-14-42-102)87(139)124-74(49-56(2)3)91(143)123-73(98(150)151)26-17-45-113-101(109)110)128-94(146)75(51-59-28-32-62(130)33-29-59)116-81(133)55-115-85(137)72(41-48-153-6)121-90(142)71(37-39-82(134)135)119-89(141)70(36-38-80(104)132)120-93(145)77(53-61-54-114-66-22-12-11-21-64(61)66)125-88(140)68(24-15-43-111-99(105)106)117-84(136)65(103)40-47-152-5/h8-12,19-22,28-35,54,56-57,65,67-79,83,114,130-131H,7,13-18,23-27,36-53,55,102-103H2,1-6H3,(H2,104,132)(H,115,137)(H,116,133)(H,117,136)(H,118,138)(H,119,141)(H,120,145)(H,121,142)(H,122,147)(H,123,143)(H,124,139)(H,125,140)(H,126,148)(H,127,144)(H,128,146)(H,134,135)(H,150,151)(H4,105,106,111)(H4,107,108,112)(H4,109,110,113)/t57-,65-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,83-/m0/s1 |
| InChIKey | WYTHCOXVWRKRAH-LOKRTKBUSA-N |
| Isomeric SMILES | CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N3CCC[C@H]3C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)CNC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCSC)N |
| Canonical SMILES | CCC(C)C(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)N3CCCC3C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)CNC(=O)C(CCSC)NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)N)NC(=O)C(CC5=CNC6=CC=CC=C65)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCSC)N |
| IUPAC Name | (4S)-4-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-oxopentanoyl]amino]-5-[[(2S)-1-[[2-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[(2S)-2-[[(2S)-1-[[(2S)-6-amino-1-[[(2S)-1-[[(1S)-4-carbamimidamido-1-carboxybutyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]carbamoyl]pyrrolidin-1-yl]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-5-oxopentanoic acid |
Description
MOTS-c
Product is sold for prescriber purposes only. Please handle with care and follow all safety guidelines for the specific chemicals involved.
MOTS-c, a mitochondrial-derived peptide, has garnered attention for its multifaceted roles in metabolic regulation, cardiovascular protection, and cellular resilience. Recent rat studies have elucidated its potential therapeutic applications across various physiological systems.
In diabetic sand rats, an eight-week regimen of moderate-intensity interval training elevated MOTS-c levels, correlating with improved insulin sensitivity and increased expression of metabolic markers such as PGC-1α, GLUT4, and AMPK. These findings suggest that MOTS-c may enhance mitochondrial biogenesis and glucose metabolism, offering a promising avenue for managing type 2 diabetes.
Beyond metabolic regulation, MOTS-c has demonstrated cardioprotective effects. In models of myocardial ischemia-reperfusion injury, MOTS-c administration suppressed ferroptosis—a form of regulated cell death—by activating the PPARγ signaling pathway. This intervention mitigated acute lung injury, highlighting MOTS-c’s potential in preserving cardiac and pulmonary function post-surgery.
Neurologically, MOTS-c exhibits protective properties against oxidative stress. In rats exposed to rotenone, a neurotoxin, MOTS-c pretreatment activated the Nrf2/HO-1/NQO1 pathway, reducing oxidative damage and preserving dopaminergic neurons. This mechanism underscores its potential in neurodegenerative disease models.
Furthermore, MOTS-c has shown efficacy in skeletal health. In osteoporotic rat models, it promoted osteogenic differentiation of bone marrow mesenchymal stem cells via the TGF-β/Smad pathway, enhancing bone formation and offering a novel approach to osteoporosis treatment.
Collectively, these studies position MOTS-c as a versatile peptide with broad therapeutic potential. Its roles in metabolic enhancement, cardiovascular protection, neuroprotection, and bone health warrant further investigation to translate these findings into clinical applications.
References
- Parseh, Sahar, et al. “An 8-Week Study on the Effects of High and Moderate-Intensity Interval Exercises on Mitochondrial MOTS-C Changes and Their Relation to Metabolic Markers in Male Diabetic Sand Rats.” Diabetes Research and Clinical Practice, vol. 212, 2024, p. 111656. https://pubmed.ncbi.nlm.nih.gov/38636847/
- Li, Y., et al. “The Mitochondrial-Derived Peptide MOTS-c Suppresses Ferroptosis and Alleviates Acute Lung Injury Induced by Myocardial Ischemia Reperfusion.” Biochemical and Biophysical Research Communications, vol. 636, 2023, pp. 1–9. https://pubmed.ncbi.nlm.nih.gov/37290680/
- Wang, X., et al. “The Mitochondrial-Derived Peptide (MOTS-c) Interacted with Nrf2 to Regulate Antioxidant Defense System in PC12 Cells and Rats.” Free Radical Biology and Medicine, vol. 193, 2023, pp. 1–10. https://pubmed.ncbi.nlm.nih.gov/37380822/
- Hu, B.-T., et al. “MOTS-c Improves Osteoporosis by Promoting Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells via TGF-β/Smad Pathway.” European Review for Medical and Pharmacological Sciences, vol. 22, no. 21, 2018, pp. 7156–7163. https://pubmed.ncbi.nlm.nih.gov/30468456/
- Zhang, L., et al. “MOTS-c Regulates the ROS/TXNIP/NLRP3 Pathway to Alleviate Myocardial Injury in Diabetic Rats.” Journal of Molecular and Cellular Cardiology, vol. 181, 2024, pp. 1–10. https://pubmed.ncbi.nlm.nih.gov/39616938/
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