NAD+ – 500mg
NAD+ – 500mg
Original price was: $129.00.$69.99Current price is: $69.99.
500mg
- This product is prepared for PRESCRIBER USE ONLY and may not be used for other purposes.
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Properties
| Molecular Formula | C21H27N7O14P2 |
|---|---|
| Molecular Weight | 663.4 |
| Monoisotopic Mass | 663.10912256 |
| Polar Area | 321 |
| Complexity | 1120 |
| XLogP | -6 |
| Heavy Atom Count | 44 |
| Hydrogen Bond Donor Count | 7 |
| Hydrogen Bond Acceptor Count | 18 |
| Rotatable Bond Count | 11 |
| Physical Appearance | Fine White Lyophilized Powder |
| Stability | Lyophilized protein is to be stored at -20°C. It is recommended to aliquot the reconstituted (dissolved) protein into several discrete vials in order to avoid repeated freezing and thawing. Reconstituted protein can be stored at 4°C |
| PubChem LCSS |
Identifiers
| CID | 5892 |
|---|---|
| CAS | 53-84-9 |
| InChI | InChI=1S/C21H27N7O14P2/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33/h1-4,7-8,10-11,13-16,20-21,29-32H,5-6H2,(H5-,22,23,24,25,33,34,35,36,37)/t10-,11-,13-,14-,15-,16-,20-,21-/m1/s1 |
| InChIKey | BAWFJGJZGIEFAR-NNYOXOHSSA-N |
| Isomeric SMILES | C1=CC(=C[N+](=C1)[C@H]2[C@@H]([C@@H]([C@H](O2)COP(=O)([O-])OP(=O)(O)OC[C@@H]3[C@H]([C@H]([C@@H](O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N |
| Canonical SMILES | C1=CC(=C[N+](=C1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)N4C=NC5=C(N=CN=C54)N)O)O)O)O)C(=O)N |
| IUPAC Name | [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate |
Description
NAD+
Product is sold for prescriber purposes only. Please handle with care and follow all safety guidelines for the specific chemicals involved.
Nicotinamide adenine dinucleotide (NAD⁺) is a vital coenzyme involved in cellular metabolism, DNA repair, and mitochondrial function. In rat models, NAD⁺ supplementation has been extensively studied, revealing its potential in mitigating various pathological conditions.
One significant area of research focuses on NAD⁺’s neuroprotective effects. In a study examining chronic cerebral hypoperfusion in rats, NAD⁺ administration improved cognitive function and reduced neuroinflammation by enhancing mitochondrial function and decreasing reactive oxygen species production. This suggests NAD⁺’s potential in treating neurodegenerative diseases.Furthermore, NAD⁺ has been implicated in enhancing exercise endurance. A study demonstrated that treatment with NAD⁺ and honokiol improved exercise capacity in rats by restoring SIRT3 levels in skeletal muscles and enhancing mitochondrial complex I levels.
Safety assessments of NAD⁺ precursors like nicotinamide riboside (NR) have also been conducted. A 90-day oral toxicity study in Sprague-Dawley rats found no adverse effects at doses up to 1,200 mg/kg/day, supporting the safe use of NR in long-term studies.
Additionally, NAD⁺ supplementation has been shown to protect against spinal cord ischemia-reperfusion injury in rats by reducing oxidative stress-induced neuronal apoptosis, highlighting its potential in treating spinal cord injuries.These findings underscore the therapeutic potential of NAD⁺ in various disease models. However, further research is necessary to fully elucidate its mechanisms and translate these benefits into clinical applications.
References
- Pei, Zuowei, et al. “The Role of NAD⁺ in Myocardial Ischemia-induced Heart Failure in Sprague-Dawley Rats and Beagles.” Current Pharmaceutical Biotechnology, vol. 25, no. 17, 2024, pp. 2300–2311. PubMed
- Ferdaus, Sara Amelia, et al. “NAD⁺ Deficiency Plays Essential Roles in the Hyperuricemia of Stroke-Prone Spontaneously Hypertensive Rat via Xanthine Dehydrogenase to Xanthine Oxidase Conversion.” Biochemical and Biophysical Research Communications, vol. 744, 2025, p. 151136. PubMed
- Zhang, Ning, et al. “NAD⁺ Improves Cognitive Function and Reduces Neuroinflammation in Rats with Chronic Cerebral Hypoperfusion.” Neuroscience Letters, vol. 748, 2021, p. 135700. PubMed
- Conze, Douglas, et al. “Safety Assessment of High-Purity, Synthetic Nicotinamide Riboside (Nicotinamide Riboside Chloride) in Sprague-Dawley Rats.” Toxicology Reports, vol. 7, 2020, pp. 1–10. PubMed
- Gökce, E. C., et al. “Protective Effect of Nicotinamide Adenine Dinucleotide Against Spinal Cord Ischemia-Reperfusion Injury in Rats.” Journal of Neurosurgery: Spine, vol. 24, no. 6, 2016, pp. 949–959. PubMed
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