Pinealon – 20mg

Pinealon

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Pinealon is a synthetic tripeptide (Glu-Asp-Arg) that has been investigated for its potential neuroprotective and anti-aging properties. Research in laboratory rats has highlighted its influence on cognitive function and neurodegenerative processes.

Studies demonstrate that the peptide can improve learning and memory in aged rats by modulating key molecular pathways involved in brain aging. In particular, it appears to regulate gene expression associated with neuronal survival and plasticity, potentially counteracting age-related cognitive decline. Rats administered this peptide showed enhanced performance in maze-based learning tasks, suggesting improved short-term and long-term memory consolidation.

One mechanism by which this peptide exerts its effects is through reducing oxidative damage in neuronal tissues. In experimental models, rats exhibited lower levels of lipid peroxidation and normalized antioxidant enzyme activity. This indicates that the peptide may help maintain redox balance in the central nervous system, thereby preserving neuronal integrity.

In addition, the peptide has been tested in rat models of Alzheimer’s-type pathology. Results showed a reduction in amyloid-beta–induced neurotoxicity and improvements in behavioral outcomes. These findings support the hypothesis that it acts as a regulator of neurodegenerative processes by influencing mitochondrial function, protein synthesis, and stress response pathways.

Overall, evidence from laboratory rat studies suggests that Pinealon may serve as a promising peptide for mitigating age-related cognitive impairment and protecting against neurodegenerative changes. However, the majority of current data is preclinical, and further research—including clinical trials—is necessary to confirm its therapeutic potential in humans.

References

1. Ashmarin, I.P., et al. (1998). Short peptides regulate gene expression in the brain of rats. Bull Exp Biol Med. [PMID: 9861694]
2. Khavinson, V.K., et al. (2002). Peptide pinealon regulates neuronal cell functions and gene expression. Neuro Endocrinol Lett. [PMID: 12500167]
3. Trofimova, S.V., et al. (2010). Pinealon reduces oxidative stress and improves learning in rats. Adv Gerontol. [PMID: 20684159]