PT-141 Peptide (Bremelanotide)
PT-141 Peptide (Bremelanotide)
Original price was: $54.99.$44.99Current price is: $44.99.
10 mg per vial
- This product is prepared for PRESCRIBER USE ONLY and may not be used for other purposes.
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Properties
| Molecular Formula | C50H68N14O10 |
|---|---|
| Molecular Weight | 1025.2 |
| Monoisotopic Mass | 1024.52428442 |
| Polar Area | 379 |
| Complexity | 1950 |
| XLogP | 0.7 |
| Heavy Atom Count | 74 |
| Hydrogen Bond Donor Count | 13 |
| Hydrogen Bond Acceptor Count | 12 |
| Rotatable Bond Count | 17 |
| Physical Appearance | Fine White Lyophilized Powder |
| Stability | Lyophilized protein is to be stored at -20°C. It is recommended to aliquot the reconstituted (dissolved) protein into several discrete vials in order to avoid repeated freezing and thawing. Reconstituted protein can be stored at 4°C |
| PubChem LCSS |
Identifiers
| CID | 9941379 |
|---|---|
| CAS | 189691.06.3 |
| InChI | InChI=1S/C50H68N14O10/c1-3-4-16-35(58-29(2)65)43(67)64-41-25-42(66)54-20-11-10-18-37(49(73)74)60-46(70)39(23-31-26-56-34-17-9-8-15-33(31)34)62-44(68)36(19-12-21-55-50(51)52)59-45(69)38(22-30-13-6-5-7-14-30)61-47(71)40(63-48(41)72)24-32-27-53-28-57-32/h5-9, 13-15, 17, 26-28, 35-41, 56H, 3-4, 10-12, 16, 18-25H2, 1-2H3, (H, 53, 57)(H, 54, 66)(H, 58, 65)(H, 59, 69)(H, 60, 70)(H, 61, 71)(H, 62, 68)(H, 63, 72)(H, 64, 67)(H, 73, 74)(H4, 51, 52, 55)/t35-, 36-, 37-, 38+, 39-, 40-, 41-/m0/s1 |
| InChIKey | FFHBJDQSGDNCIV-MFVUMRCOSA-N |
| Isomeric SMILES | CCCC[C@@H](C(=O)N[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)CC2=CN=CN2)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)O)NC(=O)C |
| Canonical SMILES | CCCCC(C(=O)NC1CC(=O)NCCCCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC1=O)CC2=CN=CN2)CC3=CC=CC=C3)CCCN=C(N)N)CC4=CNC5=CC=CC=C54)C(=O)O)NC(=O)C |
| IUPAC Name | (3S, 6S, 9R, 12S, 15S, 23S)-15-[[(2S)-2-acetamidohexanoyl]amino]-9-benzyl-6-[3-(diaminomethylideneamino)propyl]-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2, 5, 8, 11, 14, 17-hexaoxo-1, 4, 7, 10, 13, 18-hexazacyclotricosane-23-carboxylic acid |
Description
PT-141 Peptide (Bremelanotide)
Product is sold for prescriber purposes only. Please handle with care and follow all safety guidelines for the specific chemicals involved.
PT-141, also known as bremelanotide, is a synthetic peptide that acts as a non-selective agonist of melanocortin receptors, particularly MC3R and MC4R. This compound has garnered attention for its potential therapeutic applications in treating sexual dysfunctions. Preclinical studies using rat models have been instrumental in elucidating the pharmacodynamics and behavioral effects of PT-141.
In male rats, systemic administration of PT-141 has been shown to activate neurons in the hypothalamus, as evidenced by increased c-Fos immunoreactivity. This neuronal activation correlates with the induction of penile erections, suggesting that PT-141 exerts its pro-erectile effects through central melanocortin pathways. These findings underscore the compound’s potential as a centrally acting agent for erectile dysfunction.
In female rat models, PT-141 selectively enhances solicitational behaviors without affecting lordosis or general motor activity. This specificity indicates that PT-141 may modulate sexual motivation rather than general arousal or locomotion. Such selective action positions PT-141 as a promising candidate for addressing female sexual desire disorders.
Further research has explored the broader implications of melanocortin receptor agonists in sexual function. Studies suggest that these compounds can modulate sexual behaviors in both males and females, with PT-141 demonstrating efficacy in enhancing sexual responses. The central melanocortin system’s involvement in these processes highlights the therapeutic potential of targeting these pathways.
In summary, rat studies have provided valuable insights into the mechanisms by which PT-141 influences sexual behaviors. The compound’s ability to modulate central pathways associated with sexual function underscores its potential as a therapeutic agent for sexual dysfunctions. Continued research is warranted to further elucidate its mechanisms and optimize its clinical applications.
References
- Wessells, H., Hruby, V. J., Hackett, J., Han, G., Balse-Srinivasan, P., & Vanderah, T. W. (2003). PT-141: a melanocortin agonist for the treatment of sexual dysfunction. Neuroscience, 118(3), 755-762. https://pubmed.ncbi.nlm.nih.gov/12851303/
- Pfaus, J. G., Shadiack, A., Van Soest, T., Tse, M., & Molinoff, P. (2004). Selective facilitation of sexual solicitation in the female rat by a melanocortin receptor agonist. Proceedings of the National Academy of Sciences, 101(27), 10201-10204. https://pubmed.ncbi.nlm.nih.gov/15226502/
- Hadley, M. E., & Dorr, R. T. (2006). Melanocortins in the treatment of male and female sexual dysfunction. Current Topics in Medicinal Chemistry, 6(6), 603-608. https://pubmed.ncbi.nlm.nih.gov/17584134/
- Bremelanotide. (n.d.). In Wikipedia. Retrieved April 14, 2025, from https://en.wikipedia.org/wiki/Bremelanotide
- Melanocortin 4 receptor. (n.d.). In Wikipedia. Retrieved April 14, 2025, from https://en.wikipedia.org/wiki/Melanocortin_4_receptor
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