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Sermorelin – 5mg

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Sermorelin
Sermorelin

Sermorelin – 5mg

Original price was: $54.99.Current price is: $42.99.

5 mg per vial

  • This product is prepared for PRESCRIBER USE ONLY and may not be used for other purposes.
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Properties

Molecular Formula

C149H246N44O42S
Molecular Weight 3357.9
Monoisotopic Mass 3355.8186992
Polar Area 1470
Complexity7640
XLogP -12.1
Heavy Atom Count 236
Hydrogen Bond Donor Count 52
Hydrogen Bond Acceptor Count 49
Rotatable Bond Count 118
Physical Appearance Fine White Lyophilized Powder
StabilityLyophilized protein is to be stored at -20°C. It is recommended to aliquot the reconstituted (dissolved) protein into several discrete vials in order to avoid repeated freezing and thawing. Reconstituted protein can be stored at 4°C
PubChem LCSS

Sermorelin Laboratory Chemical Safety Summary

Identifiers

CID16129620
CAS86168-78-7
InChIInChI=1S/C149H246N44O42S/c1-20-77(13)116(191-122(211)81(17)168-132(221)104(66-113(204)205)178-121(210)79(15)167-123(212)88(152)62-84-39-43-86(198)44-40-84)145(234)185-102(63-83-32-23-22-24-33-83)138(227)193-118(82(18)197)146(235)186-103(65-111(155)202)137(226)189-108(71-196)142(231)182-101(64-85-41-45-87(199)46-42-85)136(225)175-93(38-31-56-165-149(161)162)126(215)174-91(35-26-28-53-151)131(220)190-115(76(11)12)143(232)184-97(58-72(3)4)124(213)166-68-112(203)170-94(47-49-109(153)200)128(217)180-100(61-75(9)10)135(224)188-106(69-194)140(229)169-80(16)120(209)172-92(37-30-55-164-148(159)160)125(214)173-90(34-25-27-52-150)127(216)179-99(60-74(7)8)134(223)181-98(59-73(5)6)133(222)176-95(48-50-110(154)201)129(218)183-105(67-114(206)207)139(228)192-117(78(14)21-2)144(233)177-96(51-57-236-19)130(219)187-107(70-195)141(230)171-89(119(156)208)36-29-54-163-147(157)158/h22-24, 32-33, 39-46, 72-82, 88-108, 115-118, 194-199H, 20-21, 25-31, 34-38, 47-71, 150-152H2, 1-19H3, (H2, 153, 200)(H2, 154, 201)(H2, 155, 202)(H2, 156, 208)(H, 166, 213)(H, 167, 212)(H, 168, 221)(H, 169, 229)(H, 170, 203)(H, 171, 230)(H, 172, 209)(H, 173, 214)(H, 174, 215)(H, 175, 225)(H, 176, 222)(H, 177, 233)(H, 178, 210)(H, 179, 216)(H, 180, 217)(H, 181, 223)(H, 182, 231)(H, 183, 218)(H, 184, 232)(H, 185, 234)(H, 186, 235)(H, 187, 219)(H, 188, 224)(H, 189, 226)(H, 190, 220)(H, 191, 211)(H, 192, 228)(H, 193, 227)(H, 204, 205)(H, 206, 207)(H4, 157, 158, 163)(H4, 159, 160, 164)(H4, 161, 162, 165)
InChIKeyWGWPRVFKDLAUQJ-UHFFFAOYSA-N
Isomeric SMILES CC[C@H](C)[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](CC3=CC=C(C=C3)O)N
Canonical SMILES CCC(C)C(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(CO)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CCC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC(C(C)CC)C(=O)NC(CCSC)C(=O)NC(CO)C(=O)NC(CCCNC(=N)N)C(=O)N)NC(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(C)NC(=O)C(CC3=CC=C(C=C3)O)N
IUPAC Name 4-[[1-[[1-[[1-[[1-[[4-amino-1-[[1-[[1-[[1-[[6-amino-1-[[1-[[1-[[2-[[5-amino-1-[[1-[[1-[[1-[[1-[[6-amino-1-[[1-[[1-[[5-amino-1-[[1-[[1-[[1-[[1-[(1-amino-5-carbamimidamido-1-oxopentan-2-yl)amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-3-carboxy-1-oxopropan-2-yl]amino]-1, 5-dioxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1, 5-dioxopentan-2-yl]amino]-2-oxoethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxohexan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-1, 4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]propanoylamino]-4-oxobutanoic acid

Description

Sermorelin

Product is sold for prescriber purposes only. Please handle with care and follow all safety guidelines for the specific chemicals involved.

Sermorelin, a synthetic analog of growth hormone-releasing hormone (GHRH), has been extensively studied in rat models to elucidate its physiological effects and therapeutic potential. These studies have provided valuable insights into the mechanisms by which sermorelin influences growth hormone (GH) secretion and its subsequent biological actions.One pivotal study demonstrated that intravenous administration of human GHRH-(1-29)NH2 in anesthetized rats elicited a dose-dependent increase in plasma GH levels. The minimal effective dose was identified as 250 ng/kg, highlighting sermorelin’s potency in stimulating GH release. This finding underscores the peptide’s potential utility in conditions characterized by GH deficiency.
Further research explored the synergistic effects of sermorelin with other GH secretagogues. In primary pituitary cell cultures, the combination of GHRH and growth hormone-releasing peptide-6 (GHRP-6) resulted in a more pronounced GH release compared to either agent alone. This synergy suggests that sermorelin could be effectively combined with other peptides to enhance GH secretion therapeutically.The metabolic stability of sermorelin has also been a subject of investigation. Studies have shown that rat GHRH-(1-29)NH2 undergoes rapid degradation in serum and liver homogenates, with half-lives of approximately 18 and 13 minutes, respectively.
This rapid catabolism necessitates modifications to improve sermorelin’s stability for clinical applications.In addition to its endocrine effects, sermorelin has been implicated in modulating inflammatory responses. Research indicates that the GHRH receptor (GHRH-R) is involved in the JAK2/STAT3 signaling pathway, which plays a role in inflammatory processes. Inhibition of this pathway in rat models led to reduced ocular inflammation, suggesting potential anti-inflammatory applications for sermorelin.Moreover, the pharmacokinetics of sermorelin analogs have been enhanced through molecular modifications. For instance, CJC-1295, a tetrasubstituted form of hGRF(1-29), exhibits prolonged presence in plasma, remaining detectable beyond 72 hours post-injection in rats. This extended half-life could improve the therapeutic efficacy of sermorelin-based treatments.Collectively, these studies underscore sermorelin’s significant impact on GH regulation and its potential therapeutic applications. Ongoing research in rat models continues to refine our understanding of sermorelin’s pharmacodynamics and optimize its clinical utility.

References:

  1. Boulanger, L., Lazure, C., Lefrançois, L., & Gaudreau, P. (1992). Catabolism of rat growth hormone-releasing factor(1-29) amide in serum and liver homogenate. Peptides, 13(4), 755-761. https://pubmed.ncbi.nlm.nih.gov/1437711/
  2. Cheng, K., Chan, W. W., Butler, B., Barreto, A., & Smith, R. G. (1989). The synergistic effects of His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 on growth hormone (GH)-releasing factor-stimulated GH release and intracellular adenosine 3′,5′-monophosphate accumulation in rat primary pituitary cell culture. Endocrinology, 124(6), 2791-2798. https://pubmed.ncbi.nlm.nih.gov/2541999/
  3. Horváth, J. E., Groot, K., & Schally, A. V. (1995). Growth hormone-releasing hormone stimulates cAMP release in superfused rat pituitary cells. Proceedings of the National Academy of Sciences, 92(6), 1856-1860. https://pubmed.ncbi.nlm.nih.gov/7892191/
  4. Liu, Y., Wang, Y., Zhang, Y., et al. (2020). Signaling mechanisms of growth hormone-releasing hormone receptor in inflammation. Proceedings of the National Academy of Sciences, 117(10), 5978-5987. https://pubmed.ncbi.nlm.nih.gov/32123064/
  5. Lapierre, H., et al. (2005). Human growth hormone-releasing factor (hGRF)1-29-albumin conjugate: pharmacokinetics and pharmacodynamics in rats. Endocrinology, 146(2), 703-708. https://pubmed.ncbi.nlm.nih.gov/15817669/

ALL LITERATURE, INFORMATION, AND DATA, PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.

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