Tesamorelin – 10mg
Tesamorelin – 10mg
Price range: $74.99 through $349.00
5 mg per vial
- This product is prepared for PRESCRIBER USE ONLY and may not be used for other purposes.
FREE & FAST SHIPPING
PUREST QUALITY
EXCELLENT SERVICE
Properties
| Molecular Formula | C221H366N72O67S |
|---|---|
| Molecular Weight | 5136 |
| Monoisotopic Mass | 5132.7166406 |
| Polar Area | 2360 |
| Complexity | 12800 |
| XLogP | -23.3 |
| Heavy Atom Count | 361 |
| Hydrogen Bond Donor Count | 83 |
| Hydrogen Bond Acceptor Count | 76 |
| Rotatable Bond Count | 187 |
| Physical Appearance | Fine White Lyophilized Powder |
| Stability | Lyophilized protein is to be stored at -20°C. It is recommended to aliquot the reconstituted (dissolved) protein into several discrete vials in order to avoid repeated freezing and thawing. Reconstituted protein can be stored at 4°C |
| PubChem LCSS |
Identifiers
| CID | 16137828 |
|---|---|
| CAS | 218949-48-5 |
| InChI | InChI=1S/C221H366N72O67S/c1-25-28-30-53-163(308)260-145(92-120-54-58-122(299)59-55-120)198(343)255-116(21)179(324)276-150(96-169(316)317)199(344)256-117(22)180(325)291-172(111(16)26-2)214(359)284-147(91-119-43-31-29-32-44-119)206(351)293-174(118(23)298)215(360)285-149(95-162(230)307)205(350)289-155(104-297)210(355)280-146(93-121-56-60-123(300)61-57-121)203(348)267-130(51-41-83-248-220(240)241)186(331)266-126(46-34-36-78-223)197(342)290-171(110(14)15)212(357)283-141(87-106(6)7)183(328)252-100-166(311)258-133(63-70-157(225)302)190(335)278-144(90-109(12)13)202(347)288-152(101-294)208(353)257-115(20)178(323)262-128(49-39-81-246-218(236)237)185(330)265-125(45-33-35-77-222)189(334)277-143(89-108(10)11)201(346)279-142(88-107(8)9)200(345)272-137(66-73-160(228)305)195(340)282-151(97-170(318)319)207(352)292-173(112(17)27-3)213(358)274-139(76-85-361-24)196(341)287-153(102-295)209(354)268-131(52-42-84-249-221(242)243)187(332)270-135(64-71-158(226)303)192(337)269-132(62-69-156(224)301)182(327)251-99-165(310)259-134(67-74-167(312)313)191(336)286-154(103-296)211(356)281-148(94-161(229)306)204(349)273-136(65-72-159(227)304)193(338)271-138(68-75-168(314)315)194(339)264-124(47-37-79-244-216(232)233)181(326)250-98-164(309)253-113(18)176(321)261-127(48-38-80-245-217(234)235)184(329)254-114(19)177(322)263-129(50-40-82-247-219(238)239)188(333)275-140(175(231)320)86-105(4)5/h28-32, 43-44, 54-61, 105-118, 124-155, 171-174, 294-300H, 25-27, 33-42, 45-53, 62-104, 222-223H2, 1-24H3, (H2, 224, 301)(H2, 225, 302)(H2, 226, 303)(H2, 227, 304)(H2, 228, 305)(H2, 229, 306)(H2, 230, 307)(H2, 231, 320)(H, 250, 326)(H, 251, 327)(H, 252, 328)(H, 253, 309)(H, 254, 329)(H, 255, 343)(H, 256, 344)(H, 257, 353)(H, 258, 311)(H, 259, 310)(H, 260, 308)(H, 261, 321)(H, 262, 323)(H, 263, 322)(H, 264, 339)(H, 265, 330)(H, 266, 331)(H, 267, 348)(H, 268, 354)(H, 269, 337)(H, 270, 332)(H, 271, 338)(H, 272, 345)(H, 273, 349)(H, 274, 358)(H, 275, 333)(H, 276, 324)(H, 277, 334)(H, 278, 335)(H, 279, 346)(H, 280, 355)(H, 281, 356)(H, 282, 340)(H, 283, 357)(H, 284, 359)(H, 285, 360)(H, 286, 336)(H, 287, 341)(H, 288, 347)(H, 289, 350)(H, 290, 342)(H, 291, 325)(H, 292, 352)(H, 293, 351)(H, 312, 313)(H, 314, 315)(H, 316, 317)(H, 318, 319)(H4, 232, 233, 244)(H4, 234, 235, 245)(H4, 236, 237, 246)(H4, 238, 239, 247)(H4, 240, 241, 248)(H4, 242, 243, 249)/b30-28+/t111-, 112-, 113-, 114-, 115-, 116-, 117-, 118+, 124-, 125-, 126-, 127-, 128-, 129-, 130-, 131-, 132-, 133-, 134-, 135-, 136-, 137-, 138-, 139-, 140-, 141-, 142-, 143-, 144-, 145-, 146-, 147-, 148-, 149-, 150-, 151-, 152-, 153-, 154-, 155-, 171-, 172-, 173-, 174-/m0/s1 |
| InChIKey | QBEPNUQJQWDYKU-BMGKTWPMSA-N |
| Isomeric SMILES | CC/C=C/CC(=O)N[C@@H](CC1=CC=C(C=C1)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC3=CC=C(C=C3)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N |
| Canonical SMILES | CCC=CCC(=O)NC(CC1=CC=C(C=C1)O)C(=O)NC(C)C(=O)NC(CC(=O)O)C(=O)NC(C)C(=O)NC(C(C)CC)C(=O)NC(CC2=CC=CC=C2)C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(CO)C(=O)NC(CC3=CC=C(C=C3)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CCC(=O)N)C(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CC(C)C)C(=O)NC(CC(C)C)C(=O)NC(CCC(=O)N)C(=O)NC(CC(=O)O)C(=O)NC(C(C)CC)C(=O)NC(CCSC)C(=O)NC(CO)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)NCC(=O)NC(CCC(=O)O)C(=O)NC(CO)C(=O)NC(CC(=O)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)O)C(=O)NC(CCCNC(=N)N)C(=O)NCC(=O)NC(C)C(=O)NC(CCCNC(=N)N)C(=O)NC(C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(C)C)C(=O)N |
| IUPAC Name | (4S)-4-[[2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S, 3S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S, 3R)-2-[[(2S)-2-[[(2S, 3S)-2-[[(2S)-2-[[(2S)-3-carboxy-2-[[(2S)-2-[[(2S)-2-[[(E)-hex-3-enoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]propanoyl]amino]propanoyl]amino]-3-methylpentanoyl]amino]-3-phenylpropanoyl]amino]-3-hydroxybutanoyl]amino]-4-oxobutanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]propanoyl]amino]-5-carbamimidamidopentanoyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-5-oxopentanoyl]amino]-3-carboxypropanoyl]amino]-3-methylpentanoyl]amino]-4-methylsulfanylbutanoyl]amino]-3-hydroxypropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]acetyl]amino]-5-[[(2S)-1-[[(2S)-4-amino-1-[[(2S)-5-amino-1-[[(2S)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-2-oxoethyl]amino]-5-carbamimidamido-1-oxopentan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-1, 5-dioxopentan-2-yl]amino]-1, 4-dioxobutan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-5-oxopentanoic acid |
Description
Tesamorelin
Product is sold for prescriber purposes only. Please handle with care and follow all safety guidelines for the specific chemicals involved.
Tesamorelin, a synthetic analogue of growth hormone-releasing hormone (GHRH), has garnered attention in rat research for its potential to modulate growth hormone (GH) secretion and influence metabolic processes. Administering tesamorelin to rats has been shown to enhance endogenous GH pulsatility, leading to increased insulin-like growth factor I (IGF-I) levels without adversely affecting insulin sensitivity. This suggests its utility in studying metabolic regulation and endocrine function in animal models.
Beyond metabolic effects, tesamorelin has demonstrated the ability to reduce muscle fat and increase muscle area in clinical studies, indicating its potential for investigating muscle composition and function in rats. Such findings are particularly relevant for exploring interventions in muscle-wasting conditions.
Additionally, tesamorelin has been observed to improve fat quality independent of changes in fat quantity, highlighting its role in adipose tissue research. This property makes it a valuable tool for studying the qualitative aspects of fat tissue and their implications on overall metabolic health.
Furthermore, research indicates that tesamorelin may enhance cognitive function, including improvements in executive function and verbal memory. These cognitive benefits open avenues for exploring its effects on brain function and neuroendocrine interactions in rodent models.
In summary, tesamorelin’s multifaceted effects on GH secretion, muscle composition, adipose tissue quality, and cognitive function make it a promising compound for comprehensive rat studies aimed at understanding metabolic and neuroendocrine dynamics.
References:
- Stanley, T. L., Chen, C. Y., Branch, K. L., Makimura, H., & Grinspoon, S. K. (2011). Effects of a growth hormone-releasing hormone analog on endogenous GH pulsatility and insulin sensitivity in healthy men. The Journal of Clinical Endocrinology & Metabolism, 96(1), 150–158. https://pubmed.ncbi.nlm.nih.gov/20943777/
- Adrian, S., Scherzinger, A., Sanyal, A., Lake, J. E., Falutz, J., Dubé, M. P., … & Erlandson, K. M. (2019). The Growth Hormone Releasing Hormone Analogue, Tesamorelin, Decreases Muscle Fat and Increases Muscle Area in Adults with HIV. The Journal of Frailty & Aging, 8(3), 154–159. https://pmc.ncbi.nlm.nih.gov/articles/PMC6766405/
- Lake, J. E., Moser, C., Johnston, L., Magyar, C., Nelson, S. D., Erlandson, K. M., … & Stanley, T. L. (2021). Tesamorelin Improves Fat Quality Independent of Changes in Fat Quantity. The Journal of Clinical Endocrinology & Metabolism, 106(7), e2710–e2718. https://pmc.ncbi.nlm.nih.gov/articles/PMC8243807/
- Baker, L. D., Barsness, S. M., Borson, S., Merriam, G. R., Friedman, S. D., Craft, S., & Peskind, E. R. (2011). O3‐07‐08: Tesamorelin, a growth hormone‐releasing hormone analogue, improves cognitive function in MCI and healthy aging: Results of a randomized controlled trial. Alzheimer’s & Dementia, 7(4), S608. https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1016/j.jalz.2011.05.1439
- Clemmons, D. R., Miller, S., & Mamputu, J. C. (2017). Safety and metabolic effects of tesamorelin, a growth hormone-releasing factor analogue, in patients with type 2 diabetes: A randomized, placebo-controlled trial. PLoS ONE, 12(6), e0179538. https://pmc.ncbi.nlm.nih.gov/articles/PMC5472315/
ALL LITERATURE, INFORMATION, AND DATA, PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.
Accurate research is our number one priority.
Same Day Shipping
Enjoy the convenience of receiving your order swiftly. We offer same-day shipping on all orders of in-stock items placed before 12:00 pm EST.
Dedicated Service
Our dedicated team is always at your service, Ready to assist you with any customer service requests you may have. We prioritize your satisfaction and aim to provide a seamless experience.
Free Shipping
To enhance your shopping experience, We offer free shipping on all orders totaling $200 or more. Rest assured, we've got you covered!
Purist Quality
We take pride in ensuring the utmost purity of our products. Every item we offer undergoes rigorous lab testing and is certified for the highest possible purity.
